Analysis performed on 2024-09-30 10:30:31
| Initial | Filtered Out | Final | Blast | |
|---|---|---|---|---|
| Bacteria | 48609 | 824 | 47785 | 26569 |
| Archaea | 3800 | 118 | 3682 | 1422 |
| Vertebrata | 1733 | 463 | 1270 | 501 |
| Mammals | 885 | 228 | 657 | 134 |
| Protein Length | Pathogenic Variants | Benign/Unknown Variants |
|---|---|---|
| 1176 | 28 | 902 |
| Domains | |
|---|---|
| Current Study | 1071, 1177 |
| Guo et al (2010) | 1064, 1176 |
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 1069 | 107 | 1176 | 9.990654 |
| Number of Variants | 839 | 91 | 930 | 9.219780 |
| Number of Pathogenic Variants | 26 | 2 | 28 | 13.000000 |
| Number of Benign/Unknown Variants | 813 | 89 | 902 | 9.134831 |
| Fisher exact test | 1.000000 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 1063 | 113 | 1176 | 9.407080 |
| Number of Variants | 830 | 100 | 930 | 8.300000 |
| Number of Pathogenic Variants | 26 | 2 | 28 | 13.000000 |
| Number of Benign/Unknown Variants | 804 | 98 | 902 | 8.204082 |
| Fisher exact test | 0.759354 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| # of sites Ancient | # sites Modern | Mean Ancient (SD) | Mean Modern (SD) | Median Ancient | Median Modern | Mann-Whitney U | p-value | |
|---|---|---|---|---|---|---|---|---|
| Current Study | 1069 | 107 | 0.81 (0.00) | 0.81 (0.02) | 7.766e-01 | 8.205e-01 | 56693.50 | 5.59e-01 |
| Guo et al (2010) | 1063 | 113 | 0.81 (0.00) | 0.81 (0.02) | 7.763e-01 | 8.206e-01 | 59008.50 | 6.20e-01 |
The Mann-Whitney U test was calculated using the conservation scores of the amino acids in ancient and modern domains. The p-value is for the null hypothesis that the conservation scores in ancient domains are greater than in modern domains.